Investigating host-retroviral interactions

HIV-1, Mx2, and the nuclear pore complex

How does nuclear pore heterogeneity affect the antiviral activity of Mx2?

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Genetic basis for retrovirus resistance

What are the genes responsible for protective antiviral responses in retrovirus resistant individuals?

Intrinsic cellular defenses

How do intrinsic innate immune effectors restrict retroviral replication?

Antiretroviral immune responses

What are the signaling pathways underlying neutralizing antiretroviral immune responses in resistant individuals?

Where we are

Children’s Hospital of Pittsburgh

Center for Microbial Pathogenesis

University of Pittsburgh School of Medicine